Overview
SCIENTIFIC SCORE
Questionable
Based on 18 Researches
6.7
USERS' SCORE
Good
Based on 6 Reviews
8.5
Supplement Facts
Serving Size: 4 Tablets
Amount Per Serving
%DV
Calories
10
Total Carbohydrate
1 g
<1%**
Dietary Fiber
1 g
4%**
Vitamin D (as cholecalciferol)
15 mcg (600 IU)
75%
Calcium (as calcium citrate)
1000 mg
77%
Sodium†
20 mg
<1%
Top Medical Research Studies
8
We explored the potential benefits of vitamin D3 supplementation in alleviating knee pain associated with osteoarthritis (OA). In this open-label clinical trial, we assessed the effects of daily doses of 4000 IU vitamin D3 over three months in 80 patients suffering from knee OA.
Our findings revealed notable improvements in pain levels and overall physical function. The patients showed significant reductions in pain scores measured by the Visual Analog Scale (VAS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) subscores after the treatment period. Remarkably, 86.7% of those treated responded positively to the therapy.
Interestingly, we observed changes in systemic cytokine levels: while some pro-inflammatory markers increased, others, including TNF-α and IL-17, showed significant reductions. This suggests that vitamin D3 not only helps with pain relief but also may influence inflammatory processes in the body.
Overall, our results indicate that vitamin D3 supplementation could be a promising therapeutic option for managing symptoms of knee OA. Nonetheless, future research should further investigate the role of specific inflammatory mediators, like IL-33, in the progression of knee osteoarthritis.
Our findings revealed notable improvements in pain levels and overall physical function. The patients showed significant reductions in pain scores measured by the Visual Analog Scale (VAS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) subscores after the treatment period. Remarkably, 86.7% of those treated responded positively to the therapy.
Interestingly, we observed changes in systemic cytokine levels: while some pro-inflammatory markers increased, others, including TNF-α and IL-17, showed significant reductions. This suggests that vitamin D3 not only helps with pain relief but also may influence inflammatory processes in the body.
Overall, our results indicate that vitamin D3 supplementation could be a promising therapeutic option for managing symptoms of knee OA. Nonetheless, future research should further investigate the role of specific inflammatory mediators, like IL-33, in the progression of knee osteoarthritis.
Read More
9
We explored how calcium phosphate (CaP) injections impact knee pain, particularly in patients suffering from osteoarthritis-related bone marrow lesions (OA-BML). In this study, we compared two groups of patients: those who received knee arthroscopy combined with CaP injections and those who had knee arthroscopy for different knee issues.
Our observations showed that patients receiving the CaP injections experienced less frequent conversions to total knee arthroplasty (TKA) when compared to the other group. Notably, within the CaP group, we noticed a significant improvement in their knee injury and functional outcome scores before and after the procedure. However, patients who only underwent knee arthroscopy did not show the same level of improvement.
Overall, we found that adding CaP injections during knee surgery for OA-BML significantly enhanced functional outcomes over traditional surgery alone. This study underscores the potential benefits of CaP treatments in managing knee pain and improving quality of life for those suffering from knee OA.
Our observations showed that patients receiving the CaP injections experienced less frequent conversions to total knee arthroplasty (TKA) when compared to the other group. Notably, within the CaP group, we noticed a significant improvement in their knee injury and functional outcome scores before and after the procedure. However, patients who only underwent knee arthroscopy did not show the same level of improvement.
Overall, we found that adding CaP injections during knee surgery for OA-BML significantly enhanced functional outcomes over traditional surgery alone. This study underscores the potential benefits of CaP treatments in managing knee pain and improving quality of life for those suffering from knee OA.
Read More
8
We investigated the role of vitamin D3 in managing post-operative knee pain in patients undergoing unicompartmental knee arthroplasty (UKA). Our study involved 240 patients divided into three groups. One group received vitamin D3 supplements before surgery, another group received them afterward, and the last group had normal vitamin D levels from the start.
By examining bone pain levels at different intervals post-surgery, we could see how vitamin D3 supplementation could affect recovery. The results showed that correcting vitamin D deficiency before surgery led to significantly better pain control afterward. It highlighted the importance of checking vitamin D levels before undergoing knee surgery, as proper treatment can enhance patient outcomes dramatically.
Overall, our findings suggest that addressing vitamin D deficiency is a critical factor for a smoother post-surgery recovery process. It not only helps in reducing pain but also may contribute to better overall knee function after surgery.
By examining bone pain levels at different intervals post-surgery, we could see how vitamin D3 supplementation could affect recovery. The results showed that correcting vitamin D deficiency before surgery led to significantly better pain control afterward. It highlighted the importance of checking vitamin D levels before undergoing knee surgery, as proper treatment can enhance patient outcomes dramatically.
Overall, our findings suggest that addressing vitamin D deficiency is a critical factor for a smoother post-surgery recovery process. It not only helps in reducing pain but also may contribute to better overall knee function after surgery.
Read More
Most Useful Reviews
9
Knees feel better
3 people found this helpful
Perfectly! I take this supplement as per my doctor's advisory. Within a month, I noticed a difference: my knees no longer caused me trouble.
Read More
10
Bone pain resolved
Love it! As a celiac, I started experiencing bone pain, but after taking this supplement, I felt significantly better in a short time. My bones and teeth are now definitely stronger, and my bone pain has vanished.
Read More
9
Pain disappeared entirely
Due to osteopenia, I often experienced throbbing and pain in my bones, particularly at bedtime. However, after using this product, that pain has completely disappeared.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 18 Researches
6.7
- All Researches
9
We focused on the effects of vitamin D (VITD) in reducing knee pain linked to osteoarthritis (OA) using a study conducted on Wistar rats. The rats were induced with OA through a combination of surgical methods known as ACLT (anterior cruciate ligament transection) along with medial meniscectomy. This allowed us to closely observe the direct impact of VITD on pain levels and cartilage health.
Our investigations revealed that VITD not only alleviated pain but also minimized cartilage destruction. We measured pain severity through various tests, examined knee structure through histopathological studies, and analyzed different biological markers including inflammatory cytokines and matrix metalloproteinases (MMPs), which are linked to cartilage degradation.
The results were quite promising. Not only did VITD show a significant reduction in pain, but it also decreased inflammation and the destruction of chondrocytes, or cartilage cells. These benefits appear to stem from VITD's ability to lower the expression of MMPs, which are known contributors to cartilage breakdown in OA.
Overall, our findings strongly suggest that adding vitamin D to treatment regimens could be beneficial for those suffering from knee pain related to osteoarthritis, making it a potential ally in managing this common joint condition.
Our investigations revealed that VITD not only alleviated pain but also minimized cartilage destruction. We measured pain severity through various tests, examined knee structure through histopathological studies, and analyzed different biological markers including inflammatory cytokines and matrix metalloproteinases (MMPs), which are linked to cartilage degradation.
The results were quite promising. Not only did VITD show a significant reduction in pain, but it also decreased inflammation and the destruction of chondrocytes, or cartilage cells. These benefits appear to stem from VITD's ability to lower the expression of MMPs, which are known contributors to cartilage breakdown in OA.
Overall, our findings strongly suggest that adding vitamin D to treatment regimens could be beneficial for those suffering from knee pain related to osteoarthritis, making it a potential ally in managing this common joint condition.
Read More
9
We explored how calcium phosphate (CaP) injections impact knee pain, particularly in patients suffering from osteoarthritis-related bone marrow lesions (OA-BML). In this study, we compared two groups of patients: those who received knee arthroscopy combined with CaP injections and those who had knee arthroscopy for different knee issues.
Our observations showed that patients receiving the CaP injections experienced less frequent conversions to total knee arthroplasty (TKA) when compared to the other group. Notably, within the CaP group, we noticed a significant improvement in their knee injury and functional outcome scores before and after the procedure. However, patients who only underwent knee arthroscopy did not show the same level of improvement.
Overall, we found that adding CaP injections during knee surgery for OA-BML significantly enhanced functional outcomes over traditional surgery alone. This study underscores the potential benefits of CaP treatments in managing knee pain and improving quality of life for those suffering from knee OA.
Our observations showed that patients receiving the CaP injections experienced less frequent conversions to total knee arthroplasty (TKA) when compared to the other group. Notably, within the CaP group, we noticed a significant improvement in their knee injury and functional outcome scores before and after the procedure. However, patients who only underwent knee arthroscopy did not show the same level of improvement.
Overall, we found that adding CaP injections during knee surgery for OA-BML significantly enhanced functional outcomes over traditional surgery alone. This study underscores the potential benefits of CaP treatments in managing knee pain and improving quality of life for those suffering from knee OA.
Read More
8
We investigated the role of vitamin D3 in managing post-operative knee pain in patients undergoing unicompartmental knee arthroplasty (UKA). Our study involved 240 patients divided into three groups. One group received vitamin D3 supplements before surgery, another group received them afterward, and the last group had normal vitamin D levels from the start.
By examining bone pain levels at different intervals post-surgery, we could see how vitamin D3 supplementation could affect recovery. The results showed that correcting vitamin D deficiency before surgery led to significantly better pain control afterward. It highlighted the importance of checking vitamin D levels before undergoing knee surgery, as proper treatment can enhance patient outcomes dramatically.
Overall, our findings suggest that addressing vitamin D deficiency is a critical factor for a smoother post-surgery recovery process. It not only helps in reducing pain but also may contribute to better overall knee function after surgery.
By examining bone pain levels at different intervals post-surgery, we could see how vitamin D3 supplementation could affect recovery. The results showed that correcting vitamin D deficiency before surgery led to significantly better pain control afterward. It highlighted the importance of checking vitamin D levels before undergoing knee surgery, as proper treatment can enhance patient outcomes dramatically.
Overall, our findings suggest that addressing vitamin D deficiency is a critical factor for a smoother post-surgery recovery process. It not only helps in reducing pain but also may contribute to better overall knee function after surgery.
Read More
8
We explored how Vitamin D affects knee pain in those suffering from knee osteoarthritis (KOA), a prevalent condition that significantly impacts the elderly. Using data from the Osteoarthritis Initiative, our analysis included 524 participants and focused on the relationship between serum Vitamin D levels and pain scores measured by the WOMAC scale.
Our findings indicated that higher levels of Vitamin D were linked to lower pain scores in men. This suggests that Vitamin D may be beneficial for male KOA patients. However, for women, we didn’t find any significant connection between Vitamin D levels and their pain scores.
We noticed a nonlinear relationship overall, which became less significant when we adjusted for other variables. This points to the possibility that Vitamin D could serve as a targeted treatment strategy for reducing knee pain in men, though it seems less effective for women. These exciting results highlight the need for further studies to verify if Vitamin D supplementation can indeed help alleviate KOA pain in male patients.
Our findings indicated that higher levels of Vitamin D were linked to lower pain scores in men. This suggests that Vitamin D may be beneficial for male KOA patients. However, for women, we didn’t find any significant connection between Vitamin D levels and their pain scores.
We noticed a nonlinear relationship overall, which became less significant when we adjusted for other variables. This points to the possibility that Vitamin D could serve as a targeted treatment strategy for reducing knee pain in men, though it seems less effective for women. These exciting results highlight the need for further studies to verify if Vitamin D supplementation can indeed help alleviate KOA pain in male patients.
Read More
8
Vitamin D aids knee pain relief
We explored how vitamin D supplementation impacts knee pain and other related factors in patients with knee osteoarthritis (KOA). A group of 165 KOA patients received 40,000 IU of vitamin D weekly for six months, and their treatment was compared against 25 healthy individuals.
Our findings revealed that patients with KOA had notably higher levels of an autophagosome protein, LC3A, compared to the healthy controls. After vitamin D supplementation, there was a significant reduction in serum LC3A levels, pointing toward an improvement in the autophagy process. This decrease in LC3A levels was also linked with a reduction in pain and better functional scores.
Additionally, we saw improvements in muscle strength and overall physical performance among those who received vitamin D. In essence, vitamin D not only helped lower inflammatory markers but also contributed to alleviating knee pain and enhancing mobility for KOA patients.
Overall, the evidence suggests that vitamin D can be an effective ally in managing knee pain and improving physical performance in individuals suffering from KOA.
Our findings revealed that patients with KOA had notably higher levels of an autophagosome protein, LC3A, compared to the healthy controls. After vitamin D supplementation, there was a significant reduction in serum LC3A levels, pointing toward an improvement in the autophagy process. This decrease in LC3A levels was also linked with a reduction in pain and better functional scores.
Additionally, we saw improvements in muscle strength and overall physical performance among those who received vitamin D. In essence, vitamin D not only helped lower inflammatory markers but also contributed to alleviating knee pain and enhancing mobility for KOA patients.
Overall, the evidence suggests that vitamin D can be an effective ally in managing knee pain and improving physical performance in individuals suffering from KOA.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Knees feel better
3 people found this helpful
Perfectly! I take this supplement as per my doctor's advisory. Within a month, I noticed a difference: my knees no longer caused me trouble.
Read More
10
Bone pain resolved
Love it! As a celiac, I started experiencing bone pain, but after taking this supplement, I felt significantly better in a short time. My bones and teeth are now definitely stronger, and my bone pain has vanished.
Read More
9
Pain disappeared entirely
Due to osteopenia, I often experienced throbbing and pain in my bones, particularly at bedtime. However, after using this product, that pain has completely disappeared.
Read More
7.5
Knee pain improved
My elbows and knees were painful. After trying various ointments and vitamins, I purchased calcium citrate with D3. Following my physician's advice, I have felt a marked reduction in daily pain, with my elbows now only occasionally aching. I'm pleased with the quality and benefits of these vitamins.
Read More
7.5
Knee pain reduced
The calcium has good bioavailability and an excellent dosage, especially with added vitamin D. Over the course of taking it, I experienced significantly less knee pain. However, the pills are quite large and tend to feel stuck in my throat, causing some discomfort in my chest.
Read More
Frequently Asked Questions
9
Knees feel better
3 people found this helpful
Perfectly! I take this supplement as per my doctor's advisory. Within a month, I noticed a difference: my knees no longer caused me trouble.
10
Bone pain resolved
Love it! As a celiac, I started experiencing bone pain, but after taking this supplement, I felt significantly better in a short time. My bones and teeth are now definitely stronger, and my bone pain has vanished.
7.5
Knee pain improved
My elbows and knees were painful. After trying various ointments and vitamins, I purchased calcium citrate with D3. Following my physician's advice, I have felt a marked reduction in daily pain, with my elbows now only occasionally aching. I'm pleased with the quality and benefits of these vitamins.
9
Pain disappeared entirely
Due to osteopenia, I often experienced throbbing and pain in my bones, particularly at bedtime. However, after using this product, that pain has completely disappeared.
7.5
Knee pain reduced
The calcium has good bioavailability and an excellent dosage, especially with added vitamin D. Over the course of taking it, I experienced significantly less knee pain. However, the pills are quite large and tend to feel stuck in my throat, causing some discomfort in my chest.
7.5
Knee pain relief
I have noticed my knees are painless after meals, yet the size of the pills makes them difficult to swallow!
7
We sought to understand the connection between vitamin D levels and knee pain in older adults suffering from osteoarthritis (OA). In our analysis, we looked at data from 105 OA patients alongside 152 control participants to explore how vitamin D deficiency might relate to functional impairment.
Our findings revealed that those with lower levels of vitamin D experienced more severe symptoms of OA. Specifically, the patients demonstrated higher levels of pain and were more functionally impaired according to the WOMAC questionnaire. Interestingly, we also found a connection between vitamin D deficiency and increased levels of inflammation markers, TNF-α and IL-6, suggesting that vitamin D may play a role in managing both pain and inflammation in OA.
Overall, this study highlights the potential importance of maintaining adequate vitamin D levels to alleviate knee pain and improve functionality in individuals with osteoarthritis. However, further research is needed to determine if vitamin D supplementation could effectively mitigate symptoms of arthritis and slow disease progression.
Our findings revealed that those with lower levels of vitamin D experienced more severe symptoms of OA. Specifically, the patients demonstrated higher levels of pain and were more functionally impaired according to the WOMAC questionnaire. Interestingly, we also found a connection between vitamin D deficiency and increased levels of inflammation markers, TNF-α and IL-6, suggesting that vitamin D may play a role in managing both pain and inflammation in OA.
Overall, this study highlights the potential importance of maintaining adequate vitamin D levels to alleviate knee pain and improve functionality in individuals with osteoarthritis. However, further research is needed to determine if vitamin D supplementation could effectively mitigate symptoms of arthritis and slow disease progression.
7
We examined the effectiveness of vitamin D treatment on knee pain in individuals suffering from knee osteoarthritis (OA). Our analysis came from a systematic review of randomized controlled trials (RCTs) that focused on how various nonsurgical treatments affected both pain levels and synovitis, or inflammation, visible through MRI scans.
The results indicated that vitamin D, alongside exercise therapy, was associated with improvements in both pain and inflammatory markers. This finding suggests that vitamin D might play a beneficial role in managing knee pain for those with OA. However, it's important to note that more research is necessary to fully understand its effects and clarify whether vitamin D alone can provide significant benefits.
Overall, this review highlights the potential of vitamin D as part of a combination treatment approach, but also emphasizes the need for further studies to validate these outcomes and explore additional therapies for knee OA treatment.
The results indicated that vitamin D, alongside exercise therapy, was associated with improvements in both pain and inflammatory markers. This finding suggests that vitamin D might play a beneficial role in managing knee pain for those with OA. However, it's important to note that more research is necessary to fully understand its effects and clarify whether vitamin D alone can provide significant benefits.
Overall, this review highlights the potential of vitamin D as part of a combination treatment approach, but also emphasizes the need for further studies to validate these outcomes and explore additional therapies for knee OA treatment.
8
We explored the potential benefits of vitamin D3 supplementation in alleviating knee pain associated with osteoarthritis (OA). In this open-label clinical trial, we assessed the effects of daily doses of 4000 IU vitamin D3 over three months in 80 patients suffering from knee OA.
Our findings revealed notable improvements in pain levels and overall physical function. The patients showed significant reductions in pain scores measured by the Visual Analog Scale (VAS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) subscores after the treatment period. Remarkably, 86.7% of those treated responded positively to the therapy.
Interestingly, we observed changes in systemic cytokine levels: while some pro-inflammatory markers increased, others, including TNF-α and IL-17, showed significant reductions. This suggests that vitamin D3 not only helps with pain relief but also may influence inflammatory processes in the body.
Overall, our results indicate that vitamin D3 supplementation could be a promising therapeutic option for managing symptoms of knee OA. Nonetheless, future research should further investigate the role of specific inflammatory mediators, like IL-33, in the progression of knee osteoarthritis.
Our findings revealed notable improvements in pain levels and overall physical function. The patients showed significant reductions in pain scores measured by the Visual Analog Scale (VAS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) subscores after the treatment period. Remarkably, 86.7% of those treated responded positively to the therapy.
Interestingly, we observed changes in systemic cytokine levels: while some pro-inflammatory markers increased, others, including TNF-α and IL-17, showed significant reductions. This suggests that vitamin D3 not only helps with pain relief but also may influence inflammatory processes in the body.
Overall, our results indicate that vitamin D3 supplementation could be a promising therapeutic option for managing symptoms of knee OA. Nonetheless, future research should further investigate the role of specific inflammatory mediators, like IL-33, in the progression of knee osteoarthritis.
8
We investigated the role of vitamin D3 in managing post-operative knee pain in patients undergoing unicompartmental knee arthroplasty (UKA). Our study involved 240 patients divided into three groups. One group received vitamin D3 supplements before surgery, another group received them afterward, and the last group had normal vitamin D levels from the start.
By examining bone pain levels at different intervals post-surgery, we could see how vitamin D3 supplementation could affect recovery. The results showed that correcting vitamin D deficiency before surgery led to significantly better pain control afterward. It highlighted the importance of checking vitamin D levels before undergoing knee surgery, as proper treatment can enhance patient outcomes dramatically.
Overall, our findings suggest that addressing vitamin D deficiency is a critical factor for a smoother post-surgery recovery process. It not only helps in reducing pain but also may contribute to better overall knee function after surgery.
By examining bone pain levels at different intervals post-surgery, we could see how vitamin D3 supplementation could affect recovery. The results showed that correcting vitamin D deficiency before surgery led to significantly better pain control afterward. It highlighted the importance of checking vitamin D levels before undergoing knee surgery, as proper treatment can enhance patient outcomes dramatically.
Overall, our findings suggest that addressing vitamin D deficiency is a critical factor for a smoother post-surgery recovery process. It not only helps in reducing pain but also may contribute to better overall knee function after surgery.
7
We explored the potential benefits of vitamin D in managing knee pain associated with osteoarthritis (OA) through a well-structured study using a rat model. The research involved dividing male Wistar rats into different groups, where some received curcumin, some received vitamin D, and others were given a combination of both, while a control group remained untreated.
Our observations indicated that vitamin D, either alone or combined with curcumin, significantly reduced pain in these models of knee OA. The combined treatment even showed enhanced pain relief compared to either supplement on its own. We also noted an increase in anti-inflammatory markers in the serum, suggesting that vitamin D helps not only in alleviating pain but also in combatting inflammation linked to OA.
Importantly, the combination of vitamin D and curcumin helped preserve joint and cartilage integrity, as revealed through histological analysis. Overall, this research suggests that vitamin D can play a vital role in managing knee pain and delaying the progression of osteoarthritis when used alongside curcumin.
Our findings support the idea that integrating natural supplements like vitamin D into treatment plans may offer meaningful relief for those suffering from knee OA.
Our observations indicated that vitamin D, either alone or combined with curcumin, significantly reduced pain in these models of knee OA. The combined treatment even showed enhanced pain relief compared to either supplement on its own. We also noted an increase in anti-inflammatory markers in the serum, suggesting that vitamin D helps not only in alleviating pain but also in combatting inflammation linked to OA.
Importantly, the combination of vitamin D and curcumin helped preserve joint and cartilage integrity, as revealed through histological analysis. Overall, this research suggests that vitamin D can play a vital role in managing knee pain and delaying the progression of osteoarthritis when used alongside curcumin.
Our findings support the idea that integrating natural supplements like vitamin D into treatment plans may offer meaningful relief for those suffering from knee OA.
3
We explored the effectiveness of vitamin D supplementation on knee pain in patients with knee osteoarthritis (KOA) through a study that emulated a randomized controlled trial using data from the Osteoarthritis Initiative. Our aim was to see if taking vitamin D could make a real difference in managing knee pain for those experiencing symptoms.
Participants included individuals aged 45 and older who hadn't taken vitamin D supplements in the past month. Those who began supplementing with at least 1,000 IU per day were compared to a control group that had not used vitamin D at all. This setup allowed us to gain insights from real-life scenarios rather than strictly controlled environments.
After two years, the results showed that vitamin D supplementation did not lead to significant changes in knee pain, as measured by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). This was also true for measures of physical function and joint space width. The effect sizes we observed were consistent with those reported in prior randomized controlled trials, which indicates a similar conclusion.
While we had hoped to find a more positive outcome, the findings suggest that vitamin D may not significantly alleviate knee pain for those with KOA. Our study contributes to the broader discussion around vitamin D's role in knee osteoarthritis management.
Participants included individuals aged 45 and older who hadn't taken vitamin D supplements in the past month. Those who began supplementing with at least 1,000 IU per day were compared to a control group that had not used vitamin D at all. This setup allowed us to gain insights from real-life scenarios rather than strictly controlled environments.
After two years, the results showed that vitamin D supplementation did not lead to significant changes in knee pain, as measured by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). This was also true for measures of physical function and joint space width. The effect sizes we observed were consistent with those reported in prior randomized controlled trials, which indicates a similar conclusion.
While we had hoped to find a more positive outcome, the findings suggest that vitamin D may not significantly alleviate knee pain for those with KOA. Our study contributes to the broader discussion around vitamin D's role in knee osteoarthritis management.
References
- Montemor CN, Fernandes MTP, Marquez AS, Bignardi PR, Poli RC, et al. Impact of Reduced Vitamin D Levels on Pain, Function, and Severity in Knee or Hip Osteoarthritis. Nutrients. 2025;17. doi:10.3390/nu17030447
- Mende LK, Kuthati Y, Wong CS. Curcumin and Vitamin D Supplement Attenuates Knee Osteoarthritis Progression in ACLT + MMx Rat Model: Effect on Cartilage Protection and Pain Reduction. Nutrients. 2025;17. doi:10.3390/nu17020349
- Rajani AM, Mittal A, Kulkarni VU, Rajani KA, Rajani KA. Role of Pre-operative Correction of Vitamin D3 Deficiency in Controlling Post-operative Bone Pain after Unicompartmental Knee Arthroplasty. Malays Orthop J. 2024;18:7. doi:10.5704/MOJ.2411.002
- Gottreich JR, Katz JN, Jones MH. Nonsurgical Knee Osteoarthritis Treatments for Reducing Inflammation as Measured on MRI Scans: A Systematic Review of Randomized Controlled Trials. Orthop J Sports Med. 2024;12:23259671241272667. doi:10.1177/23259671241272667
- Zuo A, Jia Q, Zhang M, Zhou X, Li T, et al. The association of vitamin D with knee osteoarthritis pain: an analysis from the Osteoarthritis Initiative database. Sci Rep. 2024;14:30176. doi:10.1038/s41598-024-81845-6
- Wang QW, Ong MT, Man GC, Yeung YM, He X, et al. The effectiveness of vitamin D supplementation in patients with end-stage knee osteoarthritis: Study protocol for a double-blinded, randomized controlled trial. PLoS One. 2024;19:e0309610. doi:10.1371/journal.pone.0309610
- Saengsiwaritt W, Jittikoon J, Chaikledkaew U, Tawonsawatruk T, Honsawek S, et al. Effect of vitamin D supplementation on circulating level of autophagosome protein LC3A, inflammation, and physical performance in knee osteoarthritis. Clin Transl Sci. 2023;16:2543. doi:10.1111/cts.13646
- Wang Z, Zhu Z, Pan F, Zheng S, Parameswaran V, et al. Long-term effects of vitamin D supplementation and maintaining sufficient vitamin D on knee osteoarthritis over 5 years. Arthritis Res Ther. 2023;25:178. doi:10.1186/s13075-023-03167-8
- Wang R, Wang ZM, Xiang SC, Jin ZK, Zhang JJ, et al. Relationship between 25-hydroxy vitamin D and knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials. Front Med (Lausanne). 2023;10:1200592. doi:10.3389/fmed.2023.1200592
- Busa P, Huang N, Kuthati Y, Wong CS. Vitamin D reduces pain and cartilage destruction in knee osteoarthritis animals through inhibiting the matrix metalloprotease (MMPs) expression. Heliyon. 2023;9:e15268. doi:10.1016/j.heliyon.2023.e15268
- Shen J, Lin X, Lin Y, Xiao J, Wu C, et al. Supplementation of hyaluronic acid injections with vitamin D improve knee function by attenuating synovial fluid oxidative stress in osteoarthritis patients with vitamin D insufficiency. Front Nutr. 2023;10:1026722. doi:10.3389/fnut.2023.1026722
- Divjak A, Jovanovic I, Matic A, Lucic AT, Gajovic N, et al. The influence of vitamin D supplementation on the expression of mediators of inflammation in knee osteoarthritis. Immunol Res. 2023;71:442. doi:10.1007/s12026-022-09354-0
- Lin T, Peng S, Lu S, Fu S, Zeng D, et al. Prediction of knee pain improvement over two years for knee osteoarthritis using a dynamic nomogram based on MRI-derived radiomics: a proof-of-concept study. Osteoarthritis Cartilage. 2023;31:267. doi:10.1016/j.joca.2022.10.014
- Strath LJ, Hernandez PV, Nodarse CL, Johnson AJ, Edberg JD, et al. Clinical vitamin D levels are associated with insular volume and inferior temporal gyrus white matter surface area in community-dwelling individuals with knee pain. Front Neurosci. 2022;16:882322. doi:10.3389/fnins.2022.882322
- Jin X, Ding C, Hunter DJ, Gallego B. Effectiveness of vitamin D supplementation on knee osteoarthritis - A target trial emulation study using data from the Osteoarthritis Initiative cohort. Osteoarthritis Cartilage. 2022;30:1495. doi:10.1016/j.joca.2022.06.005
- Peng HM, Weng XS, Li Y, Feng B, Qian W, et al. Effect of alendronate sodium plus vitamin D tablets on knee joint structure and osteoarthritis pain: a multi-center, randomized, double-blind, placebo-controlled study protocol. BMC Musculoskelet Disord. 2022;23:584. doi:10.1186/s12891-022-05521-4
- Rai S, Patel S, Chouhan DK, Jain A, Thami T, et al. Is There a Need for an Exogenous Activator Along with PRP for Early Knee Osteoarthritis? A Triple-Blinded Randomized Control Trial. Indian J Orthop. 2024;58:905. doi:10.1007/s43465-024-01159-7
- Stratton A, Wanless M, Abidi N. Total Knee Conversion Rates and Functional Outcome After Calcium Phosphate Injection for Bone Marrow Lesions of the Knee. J Knee Surg. 2024;37:341. doi:10.1055/a-2094-5724
